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</p> <p> messages</p> <p><h></p> <div> <p> messages from ACM,<br /> May 2014<br /> Volume fifty-seven No. 5, pages 21-23<br /> 10.1145/2591230<br /> Notes</p> <div> <figure caption> <p>A symmetrical dimer of dimers in which the amino acid (in color) folds in the cheapest possible way so that it binds better using its three gray counterparts.</p> <p><img src="https://how2soft.com/wp-content/uploads/2022/03/fix-computer-biosology.jpg" style="margin-top:20px; margin-bottom:20px; display: block; margin: 0 auto;"></p> <p>Image credit: Wiki Foldit</p> </figcaption> </div> <p> <iframe allowfullscreen="" frameborder="0" src="https://www.youtube.com/embed/lr2bB_2g_Uc"></iframe> </p> <p><a name="body-1"> </a><br /> </p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><div id="ez-toc-container" class="ez-toc-v2_0_22 counter-hierarchy counter-decimal ez-toc-grey"> <div class="ez-toc-title-container"> <p class="ez-toc-title">Table of Contents</p> <span class="ez-toc-title-toggle"><a class="ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle" style="display: none;"><i class="ez-toc-glyphicon ez-toc-icon-toggle"></i></a></span></div> <nav><ul class="ez-toc-list ez-toc-list-level-1"><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-1" href="#What_is_a_bioinformatic" title="What is a bioinformatic?">What is a bioinformatic?</a></li><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-2" href="#Why_is_Biocomputing_important" title="Why is Biocomputing important?">Why is Biocomputing important?</a></li><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-3" href="#How_are_computers_used_in_biology" title="How are computers used in biology?">How are computers used in biology?</a><ul class="ez-toc-list-level-3"><li class="ez-toc-heading-level-3"><a class="ez-toc-link ez-toc-heading-4" href="#Mobile_Calls" title="Mobile Calls">Mobile Calls</a></li></ul></li><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-5" href="#How_are_computers_used_in_biology-2" title="How are computers used in biology?">How are computers used in biology?</a></li><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-6" href="#Is_computational_biology_a_good_field" title="Is computational biology a good field?">Is computational biology a good field?</a></li><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-7" href="#Is_biocomputing_and_computational_biology_the_same" title="Is biocomputing and computational biology the same?">Is biocomputing and computational biology the same?</a></li><li class="ez-toc-page-1 ez-toc-heading-level-2"><a class="ez-toc-link ez-toc-heading-8" href="#Is_computer_science_important_for_biology" title="Is computer science important for biology?">Is computer science important for biology?</a></li></ul></nav></div> <h2 id="3"><span class="ez-toc-section" id="What_is_a_bioinformatic"></span>What is a bioinformatic?<span class="ez-toc-section-end"></span></h2> <p>= Bioinformatics is any sub-discipline of the biology of informatics that deals with the collection, storage, analysis and dissemination of biological data, primarily DNA sequences and amino acids. </p> </div> <p>Hidden <a href="https://biosology.com/">Biosology</a> modeling is not a science. The ability to extract valuable information from large amounts of data and create complex models is what changes from astronomy to quantum science. But perhaps no discipline demonstrates the tangible benefits of the computer better than biology.</p> <p></p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><h2 id="5"><span class="ez-toc-section" id="Why_is_Biocomputing_important"></span>Why is Biocomputing important?<span class="ez-toc-section-end"></span></h2> <p>Bioinformatics is important because experience does not exist in a vacuum. The 2020 coronavirus pandemic shows that rapid analysis and interpretation of data is much more effective in combating a specific distribution when this data is provided quickly and openly. But it’s not just about producing new data, there’s already so much of it every time. </p> </div> <p>“Inbreeding tracking systems have an incredible amount of valuable information built into them,” said Michael Levitt, Prof.in Structural Biology at Stanford University. “Precise and powerful connections are computers that have many possibilities to make one person another.” </p> <p></p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><h2 id="4"><span class="ez-toc-section" id="How_are_computers_used_in_biology"></span>How are computers used in biology?<span class="ez-toc-section-end"></span></h2> <p>The internal computer is an implantable device used primarily for tasks such as monitoring physical skoy activity or initiation of therapeutic effects at the molecular or cellular level. It is made up of RNA, DNA, and necessary proteins, and can also perform simple geometric calculations. </p> </div> <p>Levitt, a member of the trio that won the 2013 Nobel Prize in Chemistry, sees a biologically altered world largely thanks to computers. In recent years, he says, biologists have moved from hands-on experiments to increasingly sophisticated devices using computers and simulations. They discovered the human genome and identified long-unknown side effects of prescription drugs. Now researchers are using this knowledge to develop artificial organs that will revolutionize everything from medicine to technological innovation. Suffice it to say that this new frontier of computational biology and bioinformatics is changing our world.</p> <p>As scientists replace test tubes with hard drives, the possibilities increase. David Shaw, Principal Scientist at DE Shaw Research and Senior Scientist at Columbia University’s Center for Computational Biology and Bioinformatics, said:Computing must take its place in parallel experiments as full partners in the global scientific enterprise. serve not as a source of hypotheses, but as independent sources of verification. Each of them is able to explain natural and biochemical phenomena that are difficult for humans. The other makes possible important traditional achievements that cannot be achieved by any of the approaches alone.”</p> <p>Back to success name=”body-2″>top</p> <p><a</a></p> <h3 id="10"><span class="ez-toc-section" id="Mobile_Calls"></span>Mobile Calls<span class="ez-toc-section-end"></span></h3> <p>The origins of bioinformatics date back to the early 1970s. At this time, the Dutch theoretical biologists Paulien Hogeweg and Ben Hesper discovered the complex mathematical patterns found in the biological world, and it became possible to develop algorithms to more fully identify them. In the decades that followed, radical advances in computer processing power, memory, programming, and mathematical algorithms led to tremendous advances in this field. Computational biology and bioinformatics are commonly used today to solve problems thatThese would have been unimaginable in earlier times.</p> <p>Pavel Pevzner, professor of scientific computing at the University of California, San Diego, says computational methods are changing biology. “Biology has gone digital, and that’s true. It’s almost impossible to complete tasks in this area without learning computer tools and computer skills for several styles of martial arts.” He says computers have definitely not only opened doors, speeding up the transition from months or years of simulation to hours, they are in higher quality data and have helped researchers uncover compound and hidden relationships in certain data.</p> <p></p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><h2 id="1"><span class="ez-toc-section" id="How_are_computers_used_in_biology-2"></span>How are computers used in biology?<span class="ez-toc-section-end"></span></h2> <p>A computer is an implantable device used primarily for purposes such as monitoring the activities of the body in order to obtain therapeutic effects at any molecular or cellular level. In addition to he proteins, will consist ofDNA and a RNA will also be able to perform fairly simple mathematical calculations. </p> </div> <p>Unsurprisingly, much of the attention paid to highly publicized biology-focused projects like the Human Genome Project and The Foldit requires money in a multiplayer game leading to breakthroughs in AIDS research.</p> <p><h><br /> <block quote></p> <p>“Computing is likely to begin to take its place alongside experimentation as an essential partner in the scientific enterprise.”</p> </blockquote> <p><h></p> <p>Computer biology, in addition to computer science, has enabled the analysis and mapping of DNA and amino acid sequences in a truly dynamic way, the development and validation of pharmaceutical formulations and the creation of models for artificial sites. Scientists are also uniting research complexes to explore new territories. For example, a consortium of European scientists has developed a new computing platform called GENOBOX that could help the industry predict how food bacteria and probiotics will register in a particular human genome.</p> <p>Ron Shamir, Associate Professor of Computer Science and Scientific Bioinformatics at Tel Aviv University and ACM Fellow, says that much of the biotech revolution of the past decade has been linked to so-called next-generation sequencing, enabling ultra-fast, ultra-cheap DNA sequencing. However, because they are effective, these technologies go far beyond simple genome sequencing and are used as measurement tools for countlessx biological objects. observations, </p> <p>shamir “As sequencing prices have fallen over the past 10 years, opportunities that were once unthinkable are now available, not to mention achievable.” Human genome sequencing, which may have initially cost around $3 million, will soon cost $1,000; the cost should drop to a few hundred pieces within a few years.</p> <p><img src="https://how2soft.com/wp-content/uploads/2022/03/fix-computer-biosology-2.jpg" style="margin-top:20px; margin-bottom:20px; width: 50%; height: auto; display: block; margin: 0 auto;"></p> <p>On the other hand, these tools create significant IT challenges, especially in terms of storing, transferring and analyzing data.</p> <p>Nevertheless, huge computing power, as well as the ability to conduct research at much lower costs, are fundamentally changing the landscape of biology. For example, Levitt’s work has focused on theoretical, computational, and fundamental research on proteins and DNA, the RNA molecules responsible for life at the most fundamental level. Understanding the detailed molecular structure of biological molecules is probably an important first step towards understanding how they work and changing their function when it comes to use. drugs.</p> <p>Meanwhile, Shamir is creating and refining algorithms that allow scientists to better understand the special relationship between chromosomes and cancer, or to decipher the biological regulation of the system. The goal “is to better understand how genes are regulated by second genes and proteins,” he says. “In fact, in every cell we have a huge dynamic system that responds to specific environmental conditions and changes over time. Understanding how genes and proteins are controlled and how they change is essential for agriculture, medicine and biology. Pretty simple. </p> <p>Of course, researchers like Shaw are solving the mysteries of chemistry in new, innovative and innovative ways, especially those at the interface between the human genome and medicine. He and his research team have built a special supercomputer to simulate changes in the three-dimensional structure of a protein on a nanosecond scale. Machine processing and data has helped our own researchers unravel the molecular mechanisms that causecausing a number of biological and characteristic diseases. Many in the field believe that such advanced computer models and simulations could radically change the way drug companies develop the drugs of the future, an ideal process that has taken increasingly complex, expensive and precious times over the past few generations. It can also help reduce the use of animals for testing.</p> <p></p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><h2 id="2"><span class="ez-toc-section" id="Is_computational_biology_a_good_field"></span>Is computational biology a good field?<span class="ez-toc-section-end"></span></h2> <p>With all the advances and rapid growth in this field, there is the prospect of reliable and quality work in the coming years. In the R&D sector of biotech, pharmaceutical and scientific software companies, computational biologist is certainly a very popular job profile. </p> </div> <p>The right choice of computer allows researchers to navigate virtually any confusing array of scenarios, reproducing the body’s response to various types and levels of medical science. Over time, more and more data will connect to the machine and computer through key pins and correlations, which will likely make the model more accurate. This modeling approach integrates with traditional bioscience methods to speed up drug development and improve drug efficiency.</p> <p>Such modeling also opens up opportunities for beginners. For example, researchers from major institutesfive years ago are now involved in the artificial pancreas project, trying to help you develop and test sophisticated software that automatically controls blood sugar levels to get people with type 1 diabetes.</p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><h2 id="6"><span class="ez-toc-section" id="Is_biocomputing_and_computational_biology_the_same"></span>Is biocomputing and computational biology the same?<span class="ez-toc-section-end"></span></h2> <p>Bioinformatics is indeed an interdisciplinary field, combining physical knowledge with computer programming and authoritative big data theorems, although computational biology is an interdisciplinary field using computer science, statistics, and economics to solve problems in chemistry and biology. </p> </div> <p> </p> <div style="box-shadow: rgba(60, 64, 67, 0.3) 0px 1px 2px 0px, rgba(60, 64, 67, 0.15) 0px 1px 3px 1px;padding:20px 10px 20px 10px;"> <p><h2 id="7"><span class="ez-toc-section" id="Is_computer_science_important_for_biology"></span>Is computer science important for biology?<span class="ez-toc-section-end"></span></h2> <p>Like computers, living cells can be synthesized by algorithmic machines based on a construction scheme. 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